Endocrine Abstracts

Nectin-2, a major protein component of the adherens junctions (AJs), is found between Sertoli cells and germ cells in the seminiferious epithelium. Recent studies have shown that the expression of nectin-2 gene in testis is crucial to maintain normal spermatogenesis since male knockout mice lacking nectin-2 gene are sterile and possess morphological abnormal spermatozoa. However, the molecular mechanisms governing its basal transcription remain poorly understood. By the use of...